Contract relationships are often described as frustrating from both sides, but why? Often times, it is not realized by the players involved that the contract was established in a vacuum. The contract partner is often working against the expectations set forth in the contract in order to live up to their end of the relationship, while Pharma quality groups are often unaware of what expectations have already been set. As Quality comes into the picture and demands expectations that contradict what is in the contract, frustration levels rise….on both sides. It is critical to understand what to include in the establishment of contracts during development and commercial phases, and who should be involved in the contract review process – before it is signed. What needs to be considered from both sides of the contract – for pharma and contract manufacturers. Understand how contractual terms can drive the wrong behavior if not properly assessed – learn how to avoid common mistakes that often transcend years and create a world of angst on both sides.