From newly enacted legislation to ground-breaking domestic and international enforcement actions, the anti-corruption landscape in Latin America has changed dramatically in recent years – and responding to a corruption crisis in Latin America has become far more complicated as a result. The purpose of this chapter is to assist practitioners in navigating certain key complexities involved in managing such a crisis. First, we consider some of the background diversity in anti-corruption risks that companies confront across the region. Second, we explore some of the most important recent trends in anti-corruption enforcement in the region, including standardization in anti-corruption legislation and the increase of coordinated enforcement actions and resolutions. Finally, we focus on important ways to mitigate the challenges of navigating and avoiding a cross-border corruption crisis: whether by effectively gathering and sharing information when a problem arises, or by ensuring that compliance programmes are effectively designed and implemented with certain key elements.